Bioartificial Liver

Background and meaning

Liver function

The liver is the largest internal organ and the second largest organ. The various functions of the liver are discussed below.

It also produced prothrombin, fibrinogen, and heparin, which are necessary for blood clotting (Rad, 2020). Further

formation of carbohydrates and proteins and ketone bodies. Also, it stores fat, plasma protein, and nitrogen metabolism through the process of deamination, urea synthesis, and so on.

Basic anatomy, physiology of the liver

The liver is divided into left and right lobes by the presence of the falciform ligament. Further, two more lobes arise from the right lobe, which is called the caudate lobe and the quadrate lobe. Besides, the caudate and quadrate lobes are separated by the porta hepatis, which carry nerves, ducts, and vessels to and from the liver (May 2018).

Diseases/conditions caused by impaired liver function

Some of the causes of cirrhosis are due to prolonged hepatitis infection, chronic alcoholism, and genetic metabolic disease. Also, the liver function stops completely due to cirrhosis

Liver failure: It occurs either as a result of liver disease or as a result of liver intoxication or chronic disease.

Jaundice: The level of bilirubin along with the level of bile pigments increases. There are many causes of jaundice, but two common causes are liver and biliary tract disease.

Hemochromatosis: deposition of iron in the liver causing liver failure

Primary Biliary Cirrhosis: The bile duct is destroyed and there is permanent scarring of the liver.

Treatment: Is it necessary?

(Rad, 2020) Liver failure, or liver cirrhosis, is one of the global problems. Yet, it was found to be the highest in Egypt, Sierra Leone, Nigeria, Ethiopia, and so on (WHO, 2020).

Furthermore, from 2000-2015, it was found that in the US alone, morality furthermore, it was found that the death rate in the age group between 25-44 years i

Thus, due to the high mortality rate due to liver failure, it becomes crucial to improve its treatment process. Orthotopic liver transplantation is one solution if the liver fails to regenerate. But, to detoxify and mimic the liver function in case of liver failure, there are artificial and bioartificial livers that support the patient's health until the liver begins to regenerate or until a donor organ becomes available.

Meaning of Bioartificial vs

It shows the difference between artificial and bioartificial liver support systems

Liver function

Thus, it enables the natural process of liver regeneration, while Bioartificial can perform different liver functions. It can perform both synthetic and metabolic functions of the hepatocyte mo

Efficiency

Artificial; Very limited effectiveness, while Bioartificial High-quality results.

Use

Artificial is easy to use while Bioartificial is complex to use and maintain.